(2S,4S)-2-(Dimethylaminocarbonyl)-4-Mercapto-1- (P-Nitrobenzyloxycarbonyl)-1- Py
2S CIS PNB(SIDE CHAIN)
CAS: 96034-64-9
Molecular Formula: C15H19N3O5S
(2S,4S)-2-(Dimethylaminocarbonyl)-4-Mercapto-1- (P-Nitrobenzyloxycarbonyl)-1- Py - Names and Identifiers
(2S,4S)-2-(Dimethylaminocarbonyl)-4-Mercapto-1- (P-Nitrobenzyloxycarbonyl)-1- Py - Physico-chemical Properties
| Molecular Formula | C15H19N3O5S |
| Molar Mass | 353.39 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Melting Point | 117.0 to 121.0 °C |
| Boling Point | 555.8±50.0 °C(Predicted) |
| Flash Point | 289.9 °C |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 2.17E-12mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow to Light Yellow |
| pKa | 9.94±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.611 |
| Use | Meropenem Intermediate |
(2S,4S)-2-(Dimethylaminocarbonyl)-4-Mercapto-1- (P-Nitrobenzyloxycarbonyl)-1- Py - Reference Information
| pharmaceutical intermediates | meropenem side chain is a kind of pharmaceutical intermediates, mainly used in the production of antibiotic drugs meropenem. For the treatment of serious infections or multi-drug resistant bacteria infection patients, whether G bacteria or G-bacteria have a good effect, but not for the fight against methicillin-resistant Staphylococcus aureus. It is also not suitable for infections with other carbapenem-resistant bacteria, such as some Acinetobacter. Aminoglycosides (such as amikacin) are used if they are used against P. Aeruginosa. |
| meropenem | meropenem is another parenterally administered semi-synthetic carbapenem antibiotic following the marketing of imipenem-cilastatin in the United States. Through its covalent bond and involved in cell wall synthesis of penicillin binding protein (PBPs) binding to suppress of bacterial cell wall synthesis, so as to play an antibacterial role. The Gram-positive bacteria, gram-negative bacteria are sensitive, especially for Gram-negative bacteria have a strong antibacterial activity. If the minimum inhibitory concentration (MIC) for about 90% Enterobacter is 0.08 -0.15mg/L, more than 90% of Pseudomonas aeruginosa strains were highly sensitive (MIC<4mg/L), all Haemophilus including ampicillin-resistant strains were highly sensitive (MIC 0.06-1mg/L). Neisseria gonorrhoeae was also highly sensitive to meropenem, and its activity was 15 times higher than that of imipenem. Staphylococcus epidermidis, Staphylococcus saprophyticus and other coagulase-negative staphylococci are sensitive to meropenem, and most strains of Enterococcus faecalis are highly or moderately sensitive to meropenem. Meropenem at a concentration of 0.06-4mg/L MIC inhibits almost all Bacteroides fragilis. Anaerobic bacteria such as digestive Streptococcus, propionibacterium, actinomycetes, etc. are also sensitive to meropenem. |
| Use | meropenem intermediate |
Last Update：2024-04-09 21:32:02
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